Mouse mutations have provided tremendous insights into the molecular basis of renal and
glomerular development. However, genes often play important roles during multiple stages
of nephrogenesis, making it difficult to determine the role of a gene in a specific cell lineage
such as the podocyte. Conditional gene targeting and chimeric analysis are two possible
approaches to dissect the function of genes in specific cell populations. However, these are
labor-intensive and costly and require the generation, validation, and analysis of additional …