ACE inhibitors versus AT1 receptor antagonists in patients with chronic renal disease
KF Hilgers, JFE Mann - Journal of the American Society of …, 2002 - journals.lww.com
The success of Angiotensin-converting enzyme (ACE) inhibitors in preventing the
progression of chronic renal insufficiency has led investigators to study the effects of other
inhibitors of the renin-angiotensin system (RAS). Recently, the results of the first large-scale
trials with angiotensin II type 1 receptor (AT 1) antagonists became available (1, 2). This
article discusses the relative merits of ACE inhibitors, AT 1 antagonists, and the combination
of both drug classes in the treatment of chronic renal disease. First, we will review the …
progression of chronic renal insufficiency has led investigators to study the effects of other
inhibitors of the renin-angiotensin system (RAS). Recently, the results of the first large-scale
trials with angiotensin II type 1 receptor (AT 1) antagonists became available (1, 2). This
article discusses the relative merits of ACE inhibitors, AT 1 antagonists, and the combination
of both drug classes in the treatment of chronic renal disease. First, we will review the …