[HTML][HTML] Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 …
L Ying, BJ Morris, CD Sigmund - Journal of Biological Chemistry, 1997 - ASBMB
We examined the DNA sequence and transcription factor requirements for cAMP-induced
transactivation of the human renin promoter using Calu-6 cells that express human renin
mRNA endogenously. A series of constructs containing 896 base pairs of human renin 5′-
flanking DNA fused to the luciferase gene and containing either the native, a consensus, or
a nonfunctional cAMP response element (CRE) were used to assess DNA sequence
requirements mediating the cAMP response. Expression vectors encoding the CREB-1 …
transactivation of the human renin promoter using Calu-6 cells that express human renin
mRNA endogenously. A series of constructs containing 896 base pairs of human renin 5′-
flanking DNA fused to the luciferase gene and containing either the native, a consensus, or
a nonfunctional cAMP response element (CRE) were used to assess DNA sequence
requirements mediating the cAMP response. Expression vectors encoding the CREB-1 …