Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease
JJ Alexander, OGB Aneziokoro, A Chang… - Journal of the …, 2006 - journals.lww.com
Plasma complement factor H (Cfh) is a potent complement regulator, whereas Cfh on the
surface of rodent platelets is responsible for immune complex processing. For dissection
between the two, bone marrow chimeras between Cfh-deficient (Cfh−/−) and wild-type
C57BL/6 mice were created. Platelet Cfh protein was tracked with the Cfh status of the bone
marrow donor, indicating that platelet Cfh is of intrinsic origin. In an active model of immune
complex disease, Cfh−/− mice that were reconstituted with wild-type bone marrow had levels …
surface of rodent platelets is responsible for immune complex processing. For dissection
between the two, bone marrow chimeras between Cfh-deficient (Cfh−/−) and wild-type
C57BL/6 mice were created. Platelet Cfh protein was tracked with the Cfh status of the bone
marrow donor, indicating that platelet Cfh is of intrinsic origin. In an active model of immune
complex disease, Cfh−/− mice that were reconstituted with wild-type bone marrow had levels …