[HTML][HTML] Importance of the β12-β13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors
Type-1 protein serine/threonine phosphatases (PP1) are uniquely inhibited by the
mammalian proteins, inhibitor-1 (I-1), inhibitor-2 (I-2), and nuclear inhibitor of PP1 (NIPP-1).
In addition, several natural compounds inhibit both PP1 and the type-2 phosphatase, PP2A.
Deletion of C-terminal sequences that included the β12-β13 loop attenuated the inhibition of
the resulting PP1α catalytic core by I-1, I-2, NIPP-1, and several toxins, including tautomycin,
microcystin-LR, calyculin A, and okadaic acid. Substitution of C-terminal sequences from the …
mammalian proteins, inhibitor-1 (I-1), inhibitor-2 (I-2), and nuclear inhibitor of PP1 (NIPP-1).
In addition, several natural compounds inhibit both PP1 and the type-2 phosphatase, PP2A.
Deletion of C-terminal sequences that included the β12-β13 loop attenuated the inhibition of
the resulting PP1α catalytic core by I-1, I-2, NIPP-1, and several toxins, including tautomycin,
microcystin-LR, calyculin A, and okadaic acid. Substitution of C-terminal sequences from the …