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ResearchIn-Press PreviewNeuroscience Open Access | 10.1172/JCI173537
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Bang, S. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Jiang, C. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Xu, J. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Chandra, S. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by McGinnis, A. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Luo, X. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by He, Q. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Li, Y. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Wang, Z. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Ao, X. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Parisien, M. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Oliveira Fernandes de Araujo, L. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Jahangiri Esfahani, S. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Zhang, Q. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Tonello, R. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Berta, T. in: JCI | PubMed | Google Scholar
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Diatchenko, L. in: JCI | PubMed | Google Scholar |
1Center for Translational Pain Medicine, Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
2Faculty of Dental Medicine and Oral Health Sciences, Department of Anesthes, Alan Edwards Center for Research on Pain, McGill University, Montreal, Canada
3Department of Anesthesiology, Duke Univeristy Medical Center, Durham, United States of America
4Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, United States of America
5Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, United States of America
Find articles by Ji, R. in: JCI | PubMed | Google Scholar |
Published March 26, 2024 - More info
G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs), selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane expression in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain. GPR37L1 is co-expressed with potassium channels, including KCNJ10 (Kir4.1) in mouse SGCs and both KCNJ3 (Kir3.1) and KCNJ10 in human SGCs. GPR37L1 regulates the surface expression and function of the potassium channels. Notably, the pro-resolving lipid mediator maresin 1 (MaR1) serves as a ligand of GPR37L1 and enhances KCNJ10 or KCNJ3-mediated potassium influx in SGCs through GPR37L1. Chemotherapy suppressed KCNJ10 expression and function in SGCs, which MaR1 rescued through GPR37L1. Finally, genetic analysis revealed that the GPR37L1-E296K variant increased chronic pain risk by destabilizing the protein and impairing the protein’s function. Thus, GPR37L1 in SGCs offers a new therapeutic target for the protection of neuropathy and chronic pain.